By John G. Bartlett
Designed to supply easy access to the factors with which to struggle infectious ailment through concentrating on choice, right doses, bills, and negative effects of antimicrobial brokers, the 2004 notebook of Infectious affliction remedy attracts generally from strategies made via the facilities for ailment regulate, the scientific Letter, the yank health center Formulary provider, and the AMA's Drug reviews. Tabular fabric has been up-to-date to incorporate all newly licensed antibiotics, in addition to new techniques for administration.
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Extra info for 2004 Pocket Book of Infectious Disease Therapy
Pneumonia) strains sensitive to tetracycline, TMP-SMX, chloramphenicol Urinary tract infections Sulfa-trimethoprim Ampicillin/amoxicillin Fluoroquinolone (6) Cephalosporins (5); tetracycline (4) Septicemia I nfected prosthetic devices Vancomycin ± gentamicin or rifampin Daptomycin; linezolid; (possibly effective—chloramphenicol, rifampin, tetracycline) Stenotrophomonas maltophilia (Xanthomonas maltophilia) Septicemia, pneumonia, UTI Sulfa-trimethoprim Ceftazidime; fluoroquinolone (6);minocycline Ticarcillin-clavulanate Streptobacillus moniliformis Rat-bite fever Haverhill fever Penicillin G I V × 5–7 d, then amoxicillin × 7 d Tetracycline (4); erythromycin; clindamycin; streptomycin Streptococcus, groups B, C, G; S.
Metronidazole: Modify dose for severe hepatic failure, although specific guidelines are not provided; peak serum levels with 500 mg doses are 10–20 :g/mL. Mezlocillin: Reduce dose by 50% or double the dosing interval. Nafcillin: Metabolized by liver and largely eliminated in bile; nevertheless, dose modifications are suggested only for combined hepatic and renal failure. : Dose reduction for hepatic failure only when accompanied by renal failure. Ribavirin: AUC is unchanged wih severe hepatic failure.
3. Adjustments in subsequent doses for renally excreted drugs may be accomplished by a) giving the usual maintenance dose at extended intervals, usually three half-lives (extended interval method); b) giving reduced doses at the usual intervals (dose reduction method); or c) a combination of each. 85 Pitfalls and notations with calculations follow. a. Elderly patient: Serum creatinine may be deceptively low (with danger of overdosing) because of reduced muscle mass. b. Pregnancy, ascites, and other causes of volume expansion: GFR may be increased (with danger of underdosing) in third trimester of pregnancy and patients with normal renal function who receive massive parenteral fluids.
2004 Pocket Book of Infectious Disease Therapy by John G. Bartlett